60 SECONDS SURVIVAL GAME IGGA PLUS

Do not use an Oxford Academic personal account. When on the institution site, please use the credentials provided by your institution.Select your institution from the list provided, which will take you to your institution's website to sign in.Click Sign in through your institution.Shibboleth / Open Athens technology is used to provide single sign-on between your institutionвЂ™s website and Oxford Academic. This authentication occurs automatically,ДЄnd it is not possible to sign out of an IP authenticated account.Д¬hoose this option to get remote access when outside your institution. Typically, access is provided across an institutional network to a range of IP addresses. If you are a member of an institution with an active account, you may be able to access content in the following ways: Get help with access Institutional accessДЄccess to restricted content on Oxford Academic is often provided through institutional subscriptions and purchases. Although the OVA and influenza vaccination responses were unaffected by Se status, other measures of immune function did indicate that low Se status could adversely affect cell-mediated immunity. Whole blood mRNA expression of IL-10 was greater for SS compared with LS, AS, and SP ( P = 0.043). However, decreased mRNA expression of selected cytokines was observed in PBMC stimulated with phorbol 12-myristate 13-acetate for LS compared with AS, SP, and SS ( P < 0.05). Similarly, memory response to the influenza vaccine was not affected by Se status. Response to OVA vaccination, evaluated as OVA-specific IgG production, cytokine mRNA expression of PBMC stimulated with OVA in vitro, and lymphocyte proliferation, was unaffected by Se status. Serum vitamin E was similar between treatments. At wk 22 of the repletion phase, both Se and GSH-Px were greater for SP and SS compared with AS and LS ( P < 0.001). Blood samples were collected for 7 wk after initial vaccination for serum separation and at 0, 3, and 5 wk postvaccination for peripheral blood mononuclear cell (PBMC) isolation and whole blood cytokine mRNA evaluation. Horses were also vaccinated against equine influenza at wk 25.

At wk 22 and 25 of the repletion phase, horses were vaccinated intramuscularly with 10 mg ovalbumin (OVA). The Se status of the horses was monitored using whole blood Se and glutathione peroxidase (GSH-Px) activity as indicators.

60 SECONDS SURVIVAL GAME IGGA PLUS

A 29-wk repletion phase was as follows: LS and AS were kept on the diets fed during the depletion period, whereas SP and SS received the depletion diet plus their respective Se supplements to achieve a dietary Se concentration of 0.3 mg/kg DM. For 35 wk, horses allocated to LS, SP, and SS received a low-Se diet (0.06 mg/kg DM) with the intention to lower Se stores, whereas AS received an adequate Se diet (0.12 mg/kg DM). Twenty-eight horses were blocked by age and sex and were randomly allocated to 1 of 4 dietary treatment groups: low Se (LS), adequate Se (AS), Se-yeast (SP), and sodium selenite (SS). This study examined the effect of Se supplementation on vaccination response and immune function in mature horses. Yet few studies have focused on the effect of Se status on the equine immune system. Selenium status has been reported to affect immune function across many different species.

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